Therapy-resistant and -sensitive lncRNAs, SNHG1 and UBL7-AS1 promote glioblastoma cell proliferation

Figure 2

Dysregulated lncRNAs in various brain tumors compared with epilepsy non-tumor control brain tissues. (a) Venn diagram showing dysregulated lncRNAs by 1.0-fold or greater (p <0.05) in brain tumors such as astrocytoma (n =46), glioblastoma (n =81), and oligodendroglioma (n =50) compared with control brain tissues from epilepsy patients (n =23) from dataset GSE4290. (b (A-G) Heatmap illustrating the expression (average log expression value) of the dysregulated lncRNAs between indicated brain tumor and epilepsy non-tumor brain samples in a. (a and b-A, C, D) There were 13, 87, and 33 lncRNAs, respectively, differentially expressed in astrocytomas, GBM, and oligodendrogliomas compared with nontumor epilepsy brain samples. (a and b-B, E, G) There were 39, 11, and 10 lncRNAs, differentially expressed in astrocytomas and GBM; astrocytomas and oligodendrogliomas; GBM and oligodendrogliomas; respectively, compared with non-tumor epilepsy brain samples. (a and b-F) The expressions of 94 lncRNAs were commonly dysregulated in all tumor samples compared with non-tumor epilepsy brain samples simultaneously.

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