Therapy-resistant and -sensitive lncRNAs, SNHG1 and UBL7-AS1 promote glioblastoma cell proliferation

Figure 4

Identification of therapy-resistance and sensitive lncRNAs in GBM. (a) Venn diagram illustrating radiotherapy and TMZ/radiotherapy (21) and therapy-resistant lncRNAs (27) according to dataset GSE7696. One lncRNA LINC-PINT remained down-regulated in GBM of patients who received radiotherapy, but its expression was reversed in GBM of patients who received TMZ/radiotherapy compared with non-tumor brain tissues. The expression of two lncRNAs – PSMB8-AS1 and KB-1460A1.5 – was reversed in GBM of patients who received radiotherapy but remained down-regulated in GBM of patients who received TMZ/radiotherapy compared with non-tumor brain tissues. (b) Heatmap showing the expression (average log expression value) of therapy-resistant dysregulated lncRNAs in glioblastoma. (c) Heatmap showing the expression (average log expression value) of therapy-sensitive dysregulated lncRNAs in glioblastoma. (a and b) The expressions of 27 GBM-associated lncRNAs (identified as above) remained either up- or down-regulated in GBM of patients who received with either radiotherapy and TMZ/radiotherapy compared with control samples. (a and c) Both radiotherapy and TMZ/radiotherapy successfully reversed the expression of 21 lncRNAs in GBM.

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