The Gender-Specific Interaction of DVL3 and GSK3β Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study

Table 10

The gene-gene interaction models obtained by GMDR after gender stratification.

Samples	Locus no.	Best model	Testing accuracy (%)	CV consistency
Female	2	DVL3(rs1709642), GSK3β (rs6438552)	59.19	10/10	0.011
	3	DVL3(rs1709642), GSK3β (rs334558, rs6438552)	59.22	10/10	0.001
	4	DVL3(rs1709642), GSK3β(rs334558, rs6438552, rs2199503)	56.58	10/10	0.055
	5	DVL3(rs1709642, rs1969253), GSK3β(rs334558, rs6438552, rs2199503)	55.42	10/10	0.055
Male	2	DVL3(rs1709642), GSK3β (rs2199503)	51.17	5/10	0.377
	3	DVL3(rs1709642), GSK3β(rs6438552, rs2199503)	58.04	10/10	0.055
	4	DVL3(rs1709642), GSK3β(rs334558, rs6438552, rs2199503)	54.12	8/10	0.377
	5	DVL3(rs1709642, rs1969253), GSK3β(rs334558, rs6438552, rs2199503)	54.27	10/10	0.377

For SNP: 0=no risk alleles; 1=one risk allele; 2=two risk alleles. Adjustment for age, smoking, and alcohol drinking. Empirical value was obtained using the permutation test (1000 replication).