The Gender-Specific Interaction of DVL3 and GSK3β Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study
Table 3
Analysis on the association between DVL3/GSK3β SNPs and MDD risk.
SNP
Sample
Genotype (%)
Allele (%)
OR (95% CI)
DVL3
rs1709642
CC
CT
TT
C
T
Case
93 (17.2)
311 (57.5)
137 (25.3)
<0.01
497 (45.9)
585 (54.1)
<0.01
1.36 (1.15-1.60)
Control
174 (29.2)
289 (48.6)
132 (22.2)
637 (53.5)
553 (46.5)
rs1969253
CC
CA
AA
C
A
Case
107 (19.8)
301 (55.6)
133 (24.6)
0.035
515 (47.6)
567 (52.4)
0.105
1.21 (1.03-1.43)
Control
165 (27.7)
294 (49.4)
136 (22.9)
624 (52.4)
566 (47.6)
GSK3β
rs334558
GG
GA
AA
G
A
Case
152 (28.1)
281 (51.9)
108 (20.0)
<0.01
585 (54.1)
497 (45.9)
<0.01
1.41 (1.19-1.67)
Control
233 (39.2)
277 (46.5)
85 (14.3)
743 (62.4)
447 (37.6)
rs6438552
GG
GA
AA
G
A
Case
124 (22.9)
290 (53.6)
127 (23.5)
<0.01
538 (49.7)
544 (50.3)
<0.01
1.45 (1.23-1.71)
Control
214 (36.0)
273 (45.9)
108 (18.1)
701 (58.9)
489 (41.1)
rs2199503
AA
AG
GG
A
G
Case
185 (34.2)
261 (48.2)
95 (17.6)
0.010
631 (58.3)
451 (41.7)
<0.01
1.36 (1.14-1.61)
Control
259 (43.5)
261 (43.9)
75 (12.6)
779 (65.5)
411 (34.5)
Significant results are provided in bold after Bonferroni correction.
