The Gender-Specific Interaction of DVL3 and GSK3β Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study

Table 4

Analysis on the association between DVL3/GSK3β SNPs and MDD risk on different genetic models.

Gene	SNP	Dominant model		Recessive model
		OR (95% CI)		OR (95% CI)
DVL3	rs1709642	2.09 (1.56-2.81)	<0.01	1.19 (0.90-1.59)	0.220
	rs1969253	1.61 (1.21-2.15)	0.005	1.09 (0.82-1.45)	0.541
GSK3β	rs334558	1.72 (1.33-2.23)	<0.01	1.42 (1.03-1.95)	0.175
	rs6438552	1.94 (1.48-2.55)	<0.01	1.36 (1.01-1.83)	0.215
	rs2199503	1.49 (1.16-1.91)	0.010	1.47 (1.04-2.06)	0.140

Dominant: AA versus Aa + aa; recessive: AA + Aa versus aa (a is the minor allele). Significant results are provided in bold after Bonferroni correction. Adjustment for gender, age, smoking, and alcohol drinking.