The Gender-Specific Interaction of DVL3 and GSK3β Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study

Table 8

Association between DVL3/GSK3β SNPs and MDD in different gender subgroups.

SNP	Genotype/allele	Female			Male
		Case ()	Control ()		Case ()	Control ()
DVL3
rs1969253	CC	75 (20.3)	113 (29.7)	0.050	32 (18.7)	52 (24.3)	0.405
	CA	206 (55.7)	181 (47.5)		95 (55.6)	113 (52.8)
	AA	89 (24.0)	87 (22.8)		44 (25.7)	49 (22.9)
	C	356 (48.1)	407 (53.4)	0.200	159 (46.5)	217 (50.7)	0.246
	A	384 (51.9)	355 (46.6)		183 (53.5)	211 (49.3)
rs1709642	CC	64 (17.3)	119 (31.2)	<0.01	29 (17.0)	55 (25.7)	0.117
	CT	214 (57.8)	179 (47.0)		97 (56.7)	110 (51.4)
	TT	92 (24.9)	83 (21.8)		45 (26.3)	49 (22.9)
	C	342 (46.2)	417 (54.7)	0.001	155 (45.3)	220 (51.4)	0.094
	T	398 (53.8)	345 (45.3)		187 (54.7)	208 (48.6)
GSK3β
rs334558	GG	101 (27.3)	151 (39.6)	0.005	51 (29.8)	82 (38.3)	0.212
	GA	190 (51.3)	175 (45.9)		91 (53.2)	102 (47.7)
	AA	79 (21.4)	55 (14.5)		29 (17.0)	30 (14.0)
	G	392 (53.0)	477 (62.6)	<0.01	193 (56.4)	266 (62.1)	0.132
	A	348 (47.0)	285 (37.4)		149 (43.6)	162 (37.9)
rs6438552	GG	83 (22.4)	137 (36.0)	<0.01	41 (24.0)	77 (36.0)	0.155
	GA	193 (52.2)	176 (46.2)		97 (56.7)	97 (45.3)
	AA	94 (25.4)	68 (17.8)		33 (19.3)	40 (18.7)
	G	359 (48.5)	450 (59.1)	<0.01	179 (52.3)	251 (58.6)	0.080
	A	381 (51.5)	312 (40.9)		163 (47.7)	177 (41.4)
rs2199503	AA	124 (33.5)	165 (43.3)	0.065	61 (35.7)	94 (43.9)	0.208
	AG	176 (47.6)	164 (43.1)		85 (49.7)	97 (45.4)
	GG	70 (18.9)	52 (13.6)		25 (14.6)	23 (10.7)
	A	424 (57.3)	494 (64.8)	0.015	207 (60.5)	285 (66.6)	0.082
	G	316 (42.7)	268 (35.2)		135 (39.5)	143 (33.4)