Rutin and Quercetin Counter Doxorubicin-Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2

Figure 8

Photomicrographs of immunohistochemical sections of liver for detection of Nrf2 showing weak expression of Nrf2 in normal rats (a), very weak expression in DXR-injected rats (b), strong expression (immunopositivity indicated by brownish color) in DXR-injected rats treated with rutin (c), mild expression (immunopositivity indicated by brownish color) in DXR-injected rats treated with quercetin (d), and very weak expression in DXR-injected rats treated with a mixture of rutin and quercetin (e) (×100).

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