Rutin and Quercetin Counter Doxorubicin-Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2

Table 1

Serum parameters related to liver function in normal rats and in rats injected with DXR (without and with the supplementation of rutin and/or quercetin).

Parameter
Groups	ALT (U/L)	AST (U/L)	ALP (U/L)	Bilirubin (mg/dL)	Albumin (g/dL)
Normal control
DXR-injected control group	^++	8^++	^++	^++	^++
DXR-injected group supplemented with rutin			^$
DXR-injected group supplemented with quercetin				^$$
DXR-injected group supplemented with rutin and quercetin
-probability

Values are (). ⁺, ⁺⁺: the DXR-injected control group versus (vs.) normal control. , : the DXR-injected groups treated with rutin and/or quercetin vs. DXR-injected control group. ^$, ^$$: the DXR-injected groups treated with rutin or quercetin alone vs. DXR-injected group treated with rutin and quercetin mixture.