Rutin and Quercetin Counter Doxorubicin-Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2

Table 6

Effect on histological lesion scores of liver in normal rats and in rats injected with DXR (without and with the supplementation of rutin and/or quercetin).

Lesion score
Groups	Inflammation	Necrosis	Activated apoptosis	Vascularization of hepatocytes	Clear cells of hepatocytes	Karyomegaly of hepatocytic nuclei
Normal control
DXR-injected control group	^++	^++	^++	^++	^++	^++
DXR-injected group supplemented with rutin				^$
DXR-injected group supplemented with quercetin
DXR-injected group supplemented with rutin and quercetin
-probability

Values are (). ⁺, ⁺⁺: the DXR-injected control group vs. normal control. , : the DXR-injected groups treated with rutin and/or quercetin vs. DXR-injected control group. ^$: the DXR-injected groups treated with rutin or quercetin alone vs. DXR-injected group treated with rutin and quercetin mixture.