Mitophagy: A Potential Target for Pressure Overload-Induced Cardiac Remodelling

Figure 1

Overview of mitophagy. Mitophagy is a selective autophagy that maintains physiological functions by selectively degradation of damaged or dysfunctional mitochondria. During mitophagy, the damaged mitochondria are labeled and surrounded by vesicles which stretch to form autophagosome. Lastly, autophagosomes fuse with lysosomes to form autophagolysosomes, where hydrolases degrade the sequestered materials and released the degraded products into cytoplasm.