Review Article
Understanding the Protective Role of Exosomes in Doxorubicin-Induced Cardiotoxicity
Table 1
Summary of studies using EXOs/EVs as biomarkers for DIC diagnosis.
| EVs type | Component | Parts of EXOs/EVs | Study model | DOX administration | Distribution | Ref |
| EXOs | circ-SKA3 | circRNA | Human cardiomyocyte-like AC16 cells | 5 μM for 24 h | — | [110] | EVs | PYGB | Protein | Male C57BL/6J mice | 20 mg/kg, IP; a single dose | Serum | [107] | EXOs | miR-502 | miRNA | Dogs diagnosed with sarcoma | 30 mg/m2 for kg and 1 mg/kg for kg, IV; 2 to 3 weeks for 5 injections | Serum | [109] |
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EXOs: exosomes; EVs: extracellular vesicles; PYGB: brain/heart glycogen phosphorylase; IP: intraperitoneal injection; IV: intravenous injection.
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