Glutathione Peroxidase 4 Is a Predictor of Diabetic Kidney Disease Progression in Type 2 Diabetes Mellitus

Figure 3

Association between GPX4 expression levels and renal outcomes. (a) Kaplan-Meier analysis of GPX4-high expression group and GPX4-low expression group. (b) Nomogram of multivariable Cox regression analysis. The length of each line segment reflected the contribution of this factor to the outcome events. Point referred to the single score corresponding to each variable under different values and the total score referred to the total of the single score corresponding to the values of all variables. Then, we could predict the survival probability and median survival time of patients based on the total scores. As the psm function in the rms R package did not accept 0 as the value of variables, the patients whose survival time was less than 2 months were removed, and finally, we got 76 patients left in the nomogram. (c) Calibration curve of nomogram. eGFR: estimated glomerular filtration rate; GPX4-high: high GPX4 expression in kidney tubulointerstitium; GPX4-low: low GPX4 expression in kidney tubulointerstitium; IFTA: interstitial fibrosis and tubular atrophy; OS: overall survival.

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