Mulberrin Confers Protection against Doxorubicin-Induced Cardiotoxicity via Regulating AKT Signaling Pathways in Mice

<div>Mulberrin at the dose of 100 <i>μ</i>M attenuated the upregulation of inflammatory cytokines induced by DOX in vitro. The mRNA levels of inflammatory factors (a) were examined by qRT-PCR. The protein expression of TNF-<i>α</i> (b) and IL-6 (c) were detected by ELISA. Luciferase assay (d) was used to reflect NF-<i>κ</i>B transactivation in vitro. The nuclear accumulation of NF-<i>κ</i>B protein (e) was detected in the indicated groups. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Mulberrin Confers Protection against Doxorubicin-Induced Cardiotoxicity via Regulating AKT Signaling Pathways in Mice 