Mulberrin Confers Protection against Doxorubicin-Induced Cardiotoxicity via Regulating AKT Signaling Pathways in Mice

Figure 3

Mulberrin treatment prevented the DOX-induced cardiac dysfunction in mice. Body weight (a), heart weight (b), and myocardial LDH and CK (c, d) content were detected to evaluate DOX-induced cardiac injury. The mRNA level of ANP (e) was examined by qRT-PCR. H&E staining (f). Black line indicates myofibrillar disarrangement. Cardiac function including heart rate (g), ejection fraction (h), stroke volume (i), and cardiac output (j) was detected using an invasive hemodynamic monitoring. Data are presented as . For (a, b), each group; for (c–j), each group. compared with the saline group; ^# compared with DOX alone.

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