Mulberrin Confers Protection against Doxorubicin-Induced Cardiotoxicity via Regulating AKT Signaling Pathways in Mice

<div>Mulberrin treatment prevented the DOX-induced oxidative damage in mice. 4-Hydroxynonenal (4-HNE) immunohistochemistry of indicated groups (a). Accumulation of the oxidative stress markers, including GSH content (b), 3-NT (c), MDA content (d), and protein carbonyl content (e), was quantified by the commercial kits. Total SOD activity (f) was also detected in DOX-treated mice. Nrf2 and HO-1 protein (g) were detected in the indicated groups. The mRNA levels of Nrf2 downstream gene products (h) were also quantified. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Mulberrin Confers Protection against Doxorubicin-Induced Cardiotoxicity via Regulating AKT Signaling Pathways in Mice 