Emerging Potential Therapeutic Targets of Ferroptosis in Skeletal Diseases

Figure 1

Mechanisms of ferroptosis. Ferroptosis is characterized by iron accumulation, excessive production of ROS, and lipid peroxidation. This illustration shows the process of ferroptosis, summarizing the key molecules and targets regulating iron and lipid peroxidation. TFR1: transferrin receptor 1; PUFA: polyunsaturated fatty acid; LOX: lipoxygenase; STEAP3: six-transmembrane epithelial antigen of prostate 3 metalloreductase; SLC7A11: solute carrier family 7 member 11; DMT1: divalent metal transporter 1; SLC3A2: solute carrier family 3 member 2; BAP1: BRCA1-associated protein 1; ROS: reactive oxygen species; FSP1: ferroptosis suppressor protein 1; FPN1: ferroportin 1; GPX4: glutathione peroxidase 4; GSH; glutathione; GSSG: oxidized glutathione; GSS: glutathione synthetase; PHKG2: phosphorylase kinase G2; HSPB1: heat shock protein beta-1; NCOA4: nuclear receptor coactivator 4; RSL3: Ras-selective lethal 3.