Emerging Potential Therapeutic Targets of Ferroptosis in Skeletal Diseases

Figure 4

(a) The ultrastructure of MG63 and HOS cells (reproduced from ref. [56] with permission from 2021 Hindawi Publishing Corporation); (b) KDM4A regulation of ferroptosis and tumor progression in OS (reproduced from ref. [107] with permission from 2021 Elsevier B.V.); (c) RNA sequencing analysis of gene transcriptional profiles changings of U2os cells and Saos2 cells after treating with indicated dose of EF24 (reproduced from ref. [108] with permission from 2021 Elsevier B.V.); (d) ROS levels in MNNG/HOS, U-2 OS, MG-63, and 143B cells treated with PEITC for 24 h (reproduced from ref. [110] with permission from 2020 Hindawi Publishing Corporation).

(a)

(b)

(c)

(d)