Emerging Potential Therapeutic Targets of Ferroptosis in Skeletal Diseases

Table 3

Overview of inhibitors of ferroptosis.

Target	Inhibitor	Mechanisms associated with ferroptosis
ROS and iron ions	Minocycline	Minocycline reduces iron overload after ICH and iron induced brain injury
	Ferrostain-1	Scavenge ROS, inhibit lipid peroxidation, and reduce unstable iron in cells
	Liproxstatin-1	Scavenge ROS, inhibit lipid peroxidation, and activate the Nrf2 signaling pathway
	Curcumin	Chelate iron, reduce iron accumulation, and activate the Nrf2 signaling pathway
	Alpha tocopherol analogs	Remove ROS and inhibit lipid peroxidation
	Nitrogen oxides	Inhibit Fenton reaction and hydroxyl radical production
GSH and GPX4	Baicalein	Inhibit GSH depletion, GPX4 degradation, and lipid peroxidation and activate the Nrf2 signaling pathway
	Gastrodin	Inhibit glutamate-induced iron death in HT-22 cells
ACSL4	Rezulin	Prevention of ferroptosis and lipid peroxidation in Pfa1 cells induced by RSL3
5-LOx	Zileuton	Protect ACSL4 overexpressed LNCaP and K562 cells from erastin-induced ferroptosis
TFR1 and FTH1	HSPB1	Inhibit ferroptosis induced by erastin
Lipid peroxidation	XJB-5-131	Suppress lipid peroxidation
Iron	Deferoxamine	Deplete iron and prevent iron-dependent lipid peroxidation