Gpx3 and Egr1 Are Involved in Regulating the Differentiation Fate of Cardiac Fibroblasts under Pressure Overload

Figure 1

Overview of the fibroblast populations profiled in healthy and nonhealthy hearts. (a) Grouping and interventions in the single cell datasets. (b) The tSNE plot of nonmyocardial cells in 4 groups. (c) UMAP plot of CFs in four groups. A total of nine cell clusters were obtained. (d) Correlation heat map between clusters. The cell clusters were renamed C1 − C5 based on their correlation. (e) Relative expression levels of the marker genes for C1 − C5 shown by a bubble plot. (f) Unsupervised clustering of CFs visualized by groups. (g) FeaturePlot of some representative marker genes. (h) The proportion of C1 − C5 in each group.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)