Gpx3 and Egr1 Are Involved in Regulating the Differentiation Fate of Cardiac Fibroblasts under Pressure Overload

Figure 4

Examination of the function of upregulated genes in branch 2. (a) The top 100 hub gene network in gene cluster1 (described in Figure 2(f)), showing genes that were upregulated in branch 2. The function of these genes was classified and color-coded based on reports in the literature. (b) Differences in expression of Gpx3, Gstm1, Gsta3, Ggt5, and fibroblast-promoting genes in the different cell trajectories. (c) Heat map showing the relative expression levels of key genes related to fatty acid (FA) signals, tricarboxylic acid (TCA) cycle, glycolytic pathway, and mitochondrial respiration in each branch.

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