Association between Arsenic Level, Gene Expression in Asian Population, and In Vitro Carcinogenic Bladder Tumor

Figure 2

Global gene expression profile analysis. (a, b) A list of top 15 genes are displayed with mean decrease in accuracy value (-axis) calculated using Random Forest Approach for Data1 and Data2, respectively. The small box (right side) and color-coding bar represent the expression value (from low to high) of each gene in different conditions. (c, d) Top 30 genes identified by robust hierarchical clustering approach for Data1 and Data2, respectively. The heat map represents the gene expression value across different samples. The top line on the -axis, each box represents one sample. Two color-bar codes provide the gene expression value and condition of the sample (ultraright). (e, f) Venn diagram, overlap of most significantly differentially expressed genes and significantly associated pathways ( value ≤ 0.05) between both cohorts Data1 (blue) and Data2 (red), respectively. The complete lists of significant genes are provided in supplementary table-2, and significant pathways are in supplementary table-3.

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