Association between Arsenic Level, Gene Expression in Asian Population, and In Vitro Carcinogenic Bladder Tumor

Figure 3

Sex-dependent genetic variations. (a, b) PLS-DA plot showing the gene expression profile distribution of each sample between females (red) and males (green) for Data1 and Data2, respectively. The first two components of PLS-DA (PC1 and PC2) of gene expression profile and overall variance between the groups are displayed. Each dot represents a sample color coded by gender. (c, d) Volcano plot displays the log2 fold change and -log10 ( value) of gene expression differentiating due to gender effect for Data1 and Data2, respectively. Genes with higher than two-fold ( value ≤ 0.05) are highlighted in red. (e, f) Venn diagram, overlap of most significantly differentially expressed genes and significantly associated pathways ( value ≤ 0.05) between both cohorts Data1 (blue) and Data2 (red), respectively. The names of common genes are provided in a table (underneath). The complete lists of significant genes are provided in supplementary table-4, and significant pathways are in supplementary table-5.

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