Research Article
Harpagophytum procumbens Inhibits Iron Overload-Induced Oxidative Stress through Activation of Nrf2 Signaling in a Rat Model of Lumbar Spinal Stenosis
Figure 2
Harpagophytum procumbens (HP) regulates intraneuronal accumulation of ferritin via the transferrin receptor. (a) Representative images of ferritin (red)- and Tuj1 (green)-positive neurons in the blank, FeSO4, and HP groups. White μm; red μm. (b) Percentage of cells positive for ferritin in Tuj1-positive neurons. (c) Quantification of the percentage of transferrin-positivity in DAPI-positive neurons after treatment with HP at 50, 100, 200 μg/mL after FeSO4-treatment. (d) Representative images of transferrin expression (red) in spinal cord neurons, challenged with HP after FeSO4-treatment. White μm, yellow μm. Data are expressed as . Significant differences are indicated as #### vs. the blank group,, , and vs. the FeSO4 group, as analyzed via one-way analysis of variance with Tukey’s post hoc test.
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