Research Article
Harpagophytum procumbens Inhibits Iron Overload-Induced Oxidative Stress through Activation of Nrf2 Signaling in a Rat Model of Lumbar Spinal Stenosis
Figure 3
Harpagophytum procumbens (HP) exerts NRF2-related neuroprotection effects and promotes neurite outgrowth in FeSO4-exposed primary spinal cord neurons. (a) Representative images of NRF2 (red)- and Tuj1 (green)-positive neurons in each group. White μm; red μm. (b) Percentage of cells positive for NRF2 among Tuj1+ neurons. (c) Representative image of the F-actin (red) and Tuj1 (green) stain after laceration injury. White μm; red μm. (d–f) Quantifying the total, mean, and maximum neurite length within the lacerated area in each group. Data are expressed as the . Significant differences are indicated as #### vs. the blank group, , , , and vs. the FeSO4 group were analyzed via one-way analysis of variance with Tukey’s post hoc test.
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