Harpagophytum procumbens Inhibits Iron Overload-Induced Oxidative Stress through Activation of Nrf2 Signaling in a Rat Model of Lumbar Spinal Stenosis

Figure 5

Harpagophytum procumbens (HP) prevents upregulation of TRPV1 in dorsal root ganglions (DRG) and attenuates chronic neuropathic pain. (a) Representative immunohistochemical images of TRPV1 (green) and NeuN (red) in DRGs at 3 weeks after LSS in each group. White  μm. (b) Percentage of TRPV1⁺ neurons that colabeled with NeuN⁺ neurons in DRG. (c) Quantification of fluorescence intensity in TRPV1⁺ neuron within DRG. Data are expressed as the . Significant differences are indicated as ^#### vs. the sham group, , , and vs. the control group, as analyzed by one-way analysis of variance with Tukey’s post hoc test.

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