<i>Harpagophytum procumbens</i> Inhibits Iron Overload-Induced Oxidative Stress through Activation of <i>Nrf2</i> Signaling in a Rat Model of Lumbar Spinal Stenosis

<div><i>Harpagophytum procumbens</i> (HP) prevents iron overload-induced oxidative stress through activation of NRF2 signaling in LSS rats. (a) Representative immunohistochemical images of NRF2 (green) and ferritin (red) in the rat spinal cord at 1 week after LSS induction in each group. (b) The percentage of NRF2<sup>+</sup> or ferritin<sup>+</sup> cells to the total intensity within the rat spinal cord in each group. (c) Quantitative <i>Nrf2</i> mRNA analysis from real-time PCR at 1 and 3 weeks in each group. 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Significant differences indicated as <sup>####</sup><svg height="11.7782pt" id="M62" style="vertical-align:-3.42938pt" version="1.1" viewbox="-0.0498162 -8.34882 57.0529 11.7782" width="57.0529pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.342,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.605,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 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313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,73.351,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs. the control group were analyzed via one-way analysis of variance with Tukey’s post hoc test.</div>

Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: <i>Harpagophytum procumbens</i> Inhibits Iron Overload-Induced Oxidative Stress through Activation of <i>Nrf2</i> Signaling in a Rat Model of Lumbar Spinal Stenosis 

Figure 7 | Harpagophytum procumbens Inhibits Iron Overload-Induced Oxidative Stress through Activation of Nrf2 Signaling in a Rat Model of Lumbar Spinal Stenosis 