Harpagophytum procumbens Inhibits Iron Overload-Induced Oxidative Stress through Activation of Nrf2 Signaling in a Rat Model of Lumbar Spinal Stenosis

Figure 8

Harpagophytum procumbens (HP) protects axonal damage and improves functional recovery in lumbar spinal stenosis (LSS) model rats. (a) Representative immunohistochemical images of NF200 (green) in the rat spinal cord at 3 weeks after LSS induction in rats of each group. (b) The intensity of NF200⁺ axons in each spinal cord, including the implantation site. (c–e) Real-time PCR analysis of mRNA expression levels of regeneration-related genes, (c) Nf200, (d) Wnt5a, and (e) Wnt3 at 1 and 3 weeks in each group. (f–h) Locomotor function of LSS rats after application of HP until 3 weeks. (f) BBB score, (g) ladder score, and (h) Von Frey test. Data are expressed as the . Significant differences are indicated as ^#, ^##, ^###, and ^#### vs. the sham group, , , , and vs. the control group, as analyzed via one-way or two-way analysis of variance with Tukey’s post hoc test.

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