Research Article
The Effect of miR-505-5p on Inhibition of Serum Uromodulin Ameliorates Myocardial Inflammation and Apoptosis Induced by Ischemia-Reperfusion
Figure 4
miR-505-5p overexpression attenuated I/R-induced myocardial injury. (a) The expression of miR-505-5p in I/R myocardium with ov-miR-505-5p and ov-sUmod was analyzed by qRT-PCR.(b–d) Western blot and qRT-PCR were used to analyze the effects of ov-miR-505-5p and ov-sUmod on sUmod protein and mRNA expression in myocardial I/R injury. (e) The effect of ov-miR-505-5p and ov-sUmod on heart weight/body weight ratio. (f and i) The effects of ov-miR-505-5p and ov-sUmod on serum cardiac enzymes BNP (f), LDH (g), cTnl (h), and CK (i). vs. Sham; # vs. I/R; & vs. ov- miR-505-5p.
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