circHtra1/miR-3960/GRB10 Axis Promotes Neuronal Loss and Immune Deficiency in Traumatic Brain Injury

Figure 6

Plasma NK cell reduction in TBI. (a, b) CIBERSORT and QuanTIseq were used to assess immune infiltration in TBI. (c, d) Quantification of results shown in panels (a) and (b), showing that the percentage of NK cells decreases in moderate or severe TBI. (e, f) The percentage of NK cells is lower in severe TBI than in the mild group and is positively correlated with plasma NK (%). (g, h) The expression of GRB10 in TBI, and its correlation with GCS. (i–k) The relative plasma NK ratio (reflected by CD3- CD56+) in severe TBI (i); moderate TBI (j), and mild TBI (k). (l) The CIBERSORT method shows the immune cells distribution in plasma of TBI patients and healthy controls. (m, n) The cell communication in the blood from sc-seq data in healthy controls (m) and TBI patients (n).

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)

(m)

(n)