Theaflavin-3,3-Digallate Inhibits Erastin-Induced Chondrocytes Ferroptosis via the Nrf2/GPX4 Signaling Pathway in Osteoarthritis

Figure 1

The Gpx4 expression was downregulated in cultured chondrocytes from OA patients. (a) Gpx4 protein expression in chondrocytes from trauma patients (HC1 to HC4: chondrocytes from 4 different trauma controls) and OA patients (OA1 to OA4: OA chondrocytes from 4 different OA patients). (b) The mRNA levels of Gpx4 in the chondrocytes from trauma patients (as healthy control, ) and OA patients () were examined by qPCR. Data were compared by unpaired -test, . HC: healthy control; OA: osteoarthritis; Gpx4: glutathione peroxidase 4.

(a)

(b)