Theaflavin-3,3<span class="nowrap"><svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-0.06579971pt" id="M1" height="10.38pt" version="1.1" viewBox="-0.0657574 -10.3142 5.9878 10.38" width="5.9878pt"><g transform="matrix(.017,0,0,-0.017,0,0)"><path id="g113-31" d="M295 534L291 558C277 573 202 603 180 597L75 72L120 51L295 534Z"/></g></svg>-</span>Digallate Inhibits Erastin-Induced Chondrocytes Ferroptosis via the Nrf2/GPX4 Signaling Pathway in Osteoarthritis

<div>TF3 reverses erastin-induced chondrocyte viability. (a) Chemical structure diagram of TF3. (b) Chondrocytes were treated with different concentrations of erastin (1 <i>μ</i>M, 2 <i>μ</i>M, 5 <i>μ</i>M, 10 <i>μ</i>M, and 20 <i>μ</i>M) for 24 hrs. (c, d) Chondrocytes were treated with different concentrations of TF3 for 12 hrs or 24 hrs. (e) Chondrocytes were pretreated with TF3 (15 <i>μ</i>M/30 <i>μ</i>M) for 2 hours and then stimulated with erastin (5 <i>μ</i>M) for 24 hrs. The results are presented as the <svg height="9.10327pt" id="M26" style="vertical-align:-0.3499298pt" version="1.1" viewbox="-0.0498162 -8.75334 58.1969 9.10327" width="58.1969pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M797 0V26C739 32 732 36 732 103V296C732 394 682 449 605 449C576 449 550 437 529 423C504 407 475 389 446 366C425 418 382 449 334 449C303 449 279 437 253 421C222 403 201 385 180 371V452C135 432 85 419 41 411V388C99 379 102 374 102 310V103C102 38 93 32 27 26V0H238V26C189 32 180 38 180 103V338C210 363 250 390 289 390C351 390 377 348 377 275V103C377 37 368 32 306 26V0H520V26C465 32 456 38 456 101V296C456 314 455 326 453 338C491 369 529 390 565 390C628 390 653 345 653 274V107C653 36 642 32 583 26V0H797Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.595,0)"><path d="M380 106C343 72 306 56 265 56C195 56 116 112 115 248C235 252 361 262 377 265C396 269 400 277 400 297C400 374 333 449 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598 226 604C236 612 262 617 304 617C371 617 429 604 474 576C554 529 592 439 592 336C592 176 505 36 319 36C246 36 213 55 213 131V547Z"></path></g></svg> of three independent experiments, and statistical significance was determined by one-way ANOVA. <span class="nowrap"><svg height="13.532pt" id="M27" style="vertical-align:-3.4295pt" version="1.1" viewbox="-0.0498162 -10.1025 50.6052 13.532" width="50.6052pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Theaflavin-3,3<span class="nowrap"><svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-0.06579971pt" id="M1" height="10.38pt" version="1.1" viewBox="-0.0657574 -10.3142 5.9878 10.38" width="5.9878pt"><g transform="matrix(.017,0,0,-0.017,0,0)"><path id="g113-31" d="M295 534L291 558C277 573 202 603 180 597L75 72L120 51L295 534Z"/></g></svg>-</span>Digallate Inhibits Erastin-Induced Chondrocytes Ferroptosis via the Nrf2/GPX4 Signaling Pathway in Osteoarthritis 

Oxidative Medicine and Cellular Longevity

Theaflavin-3,3-Digallate Inhibits Erastin-Induced Chondrocytes Ferroptosis via the Nrf2/GPX4 Signaling Pathway in Osteoarthritis

Figure 2