Research Article
Pterostilbene Attenuates Subarachnoid Hemorrhage-Induced Brain Injury through the SIRT1-Dependent Nrf2 Signaling Pathway
Figure 4
Influence of PTE on SIRT1-mediated Nrf2 cascade. Western blot images for SIRT1-mediated Nrf2 cascade (a). PTE markedly induced the expression of SIRT1 (b), nucleus Nrf2 (c), HO-1 (d), SOD-1 (e), and NQO-1 (f). In contrast, EX527 diminished the influence of PTE on SIRT1-mediated Nrf2 cascade (/groups). Immunofluorescence of SIRT1 (g) and Nrf2 staining (i). PTE markedly induced the expressions of SIRT1 (h) and nuclear Nrf2 in neurons (j), which could be abolished by EX527 (/groups). One-way ANOVA with Bonferroni post hoc test was employed. Scale bar, 50 μm. Error bars indicated the SD. .
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