Change in Oxidative Stress and Mitochondrial Dynamics in Response to Elevated Cold-Inducible RNA-Binding Protein in Cardiac Surgery-Associated Acute Kidney Injury

Figure 4

CPB aggravated inflammatory cell infiltration and renal oxidative stress. (a) Immune cell infiltration of macrophages and neutrophils in rat renal tissue at 4 hours after CPB (magnification 400x); quantification of inflammatory cells in renal tissue after CPB; CPB aggravated immune cell infiltration in both the outer medulla and cortex. (b) F4/80-positive macrophages in the outer medulla. (c) F4/80-positive macrophages in the cortex. (d) MPO-positive neutrophils in the outer medulla. (e) MPO-positive neutrophils in the cortex. (f–h) MDA, GSH, and SOD levels in the renal tissue of each group. CPB: cardiopulmonary bypass; MDA: malonaldehyde; GSH: glutathione; SOD: superoxide dismutase. vs. sham; ^# vs. CPB. (a) Scale bars: 200 μm.

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