Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway

Figure 1

Schematic timeline of the experimental procedure. The mice were acclimatized to the laboratory environment for 7 days before the studies. The EX-527 or corresponding vehicle was injected daily for 3 days before surgery; the MSCs-Exo, or Fer-1, or corresponding vehicle was administered 1 hour before surgery. Next, the behavioral tests were performed began at the 24 hours after the surgery to verify the success of model and the influence of MSCs-Exo on cognitive function in dNCR aged mice. In the end, the mice were decapitated after the behavioral tests, and the brain tissues were collected for subsequent experiments.