Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway

Figure 10

Diagrammatic presentation of the findings from this study. MSCs-Exo upregulates the expression level of SIRT1. SIRT1 restoration leads to an increase in Nrf2 and HO-1. Collectively, this mechanism inhibits ferroptosis induced by surgery so as to alleviate cognitive impairment. MSCs: mesenchymal stem cells; MSCs-Exo: mesenchymal stem cell-derived exosomes; dNCR: delayed neurocognitive recovery; SIRT1: silent information regulator 1; Nrf2: factor nuclear factor-erythroid 2-related factor 2; HO-1: heme oxygenase-1.