Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway

<div>Surgery induced cognitive impairment in aged mice. The mice were randomly divided into 3 groups: Sham group, dNCR group, and dNCR+Fer-1 group. (a) Escape latency during the MWM navigation test. (b) The representative trajectory diagrams of the swimming distance to find the platform (blue dots: starting position; yellow dots: ending position). (c) The platform-crossing times in the MWM test. (d) The time spent in the target quadrant during the MWM test. 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Fer-1: ferrostatin-1, a ferroptosis inhibitor.</div>

Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway 

Figure 2 | Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway 