Research Article
Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway
Figure 7
The effect of MSCs-Exo on hippocampus ferroptosis in dNCR mice is mediated by the Nrf2/HO-1 signaling pathway. The mice were randomly divided into 4 groups: Sham group, dNCR group, dNCR+MSCs-Exo group, and dNCR+Fer-1 group. (a–c) Nrf2 and HO-1 expressions in each group were determined by Western blot. Data are expressed as (/group). and , Sham vs. dNCR; ## and ###, dNCR vs. dNCR+ MSCs-Exo; @@ and @@@, dNCR vs. dNCR+Fer-1. Fer-1: ferrostatin-1, a ferroptosis inhibitor.
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