Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway

Figure 8

MSCs-Exo alleviated cognitive impairment of dNCR mice in a SIRT1-dependent manner. The mice were randomly divided into 5 groups: Sham group, dNCR group, dNCR+MSCs-Exo group, dNCR+MSCs-Exo + EX-527 group, and dNCR+EX-527 group. (a, b) SIRT1 expression in each group was determined by Western blot. (c) Escape latency during the MWM navigation test. (d) The representative trajectory diagrams of the swimming distance to find the platform (blue dots: starting position; yellow dots: ending position). (e) The platform-crossing times in the MWM test. (f) The time spent in the target quadrant during the MWM test. Data are expressed as (/group). , , and , Sham vs. dNCR or Sham vs. dNCR+EX-527; ^# and ^##, dNCR vs. dNCR+MSCs-Exo; ^$ and ^$$, dNCR+MSCs-Exo vs. dNCR+MSCs-Exo + EX-527. EX-527: a specific SIRT1 inhibitor.

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