Establishment of a Prognostic Prediction and Drug Selection Model for Patients with Clear Cell Renal Cell Carcinoma by Multiomics Data Analysis

Figure 4

Landscape of somatic mutation in the CS1 and CS2 subgroups. (a, b) Waterfall plot shows the mutation distribution of the top 20 most frequently mutated genes. The central panel shows the type of mutation in each ccRCC sample. The upper panel shows the mutation frequency of each ccRCC sample. The bar plots on the left show the frequency and mutation type of genes mutated in 258 ccRCC samples. The lower part shows different subgroups including CS1 and CS2. (c) Forest plot displays the top 6 most significantly differentially mutated genes between the two subgroups. (d) Heatmap illustrates the mutually cooccurring and exclusive mutations of the top 25 frequently mutated genes. The color and symbol in each cell represent the statistical significance of the exclusivity or cooccurrence for each pair of genes.

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