Dietary Fatty Acid Regulation of the NLRP3 Inflammasome via the TLR4/NF-κB Signaling Pathway Affects Chondrocyte Pyroptosis

Figure 4

Effects of dietary FAs on TLR4/NF-κB signals and NLRP3 inflammasome as well as its downstream signals in articular cartilage of mice. (a) The relative expression of TLR4, MyD88, and p-NF-κB protein of knee articular cartilage was detected by Western blot. (b–d) Immunohistochemical staining was used to measure NLRP3, caspase-1, and IL-1β positive cells (200x,  μm). The data are presented as the , . and versus the LD group; ^# and ^## versus the sham group; ^ and ^^ versus the SFA group; ^& and ^&& versus the MUFA group; ^$ and ^$$ versus the n-6 group.

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