The Ameliorative Role of Eugenol against Silver Nanoparticles-Induced Hepatotoxicity in Male Wistar Rats

Figure 10

Periportal zones of hepatic tissues stained with H&E revealing (a) regular hepatic architecture with well-organized radiating hepatic strands (HS) surrounding the portal tract that formed of regular hepatic portal artery (PA), hepatic portal vein (PV), and bile ductule (BD) in control rats; (b) regular hepatic structure in Eug-treated rats; (c) devastated hepatic portal artery (PA), hepatic portal vein (PV), and bile ductule (BD) with thickened boundaries, infiltrating inflammatory cells (IC) in the surrounding connective tissues and inside their lumina, besides necrotic hepatocytes with pyknotic (Pk) or karyolysed (KI) nuclei and blood sinusoids (BS) having swollen Kupffer cells (KC) pushed in their lumens are obviously noticed in AgNPs-low-dose-treated rats; (d) severely dilated and congested hepatic portal vein (PV) and portal artery (PA) having stagnant blood masses (SHB) and infiltrating inflammatory cells (IC) in their lumens and also aggregated outside them, besides deteriorated bile ductules (BD) with thickened and deformed epithelia. Also, disorderly hepatic strands with necrotic hepatocytes having pyknotic (PK) nuclei are observed in AgNPs-high-dose-treated rats; (e) conspicuous improvement in the histological structure of the hepatic tissues with intact portal triad and hepatic strands in Eug + AgNPs-low-dose-treated rats; (f) restoration of the hepatic architecture with few infiltrating inflammatory cells (IC) and hepatocytes with pyknotic (Pk) nuclei are noticed in Eug + AgNPs-high-dose-treated rats.

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