The Ameliorative Role of Eugenol against Silver Nanoparticles-Induced Hepatotoxicity in Male Wistar Rats
Table 2
Histomorphometrical analysis of the hepatic tissue components in control and treated animal groups.
Parameters
Animal groups
Control
Eug
AgNPs-low dose
AgNPs-high dose
Eug + AgNPs-low dose
Eug + AgNPs-high dose
Number of normal hepatocytes
a
a
b
c
a
b
% change
0
-5.06%
-17.72%
-44.30%
-8.23%
-24.05%
Number of necrotic hepatocytes
f
e
c
a
d
b
% change
0
38.46%
288.46%
1126.92%
142.31%
315.38%
Number of deteriorated Kupffer cells
d
d
c
a
d
b
% change
0
16.67%
95.00%
383.33%
35.00%
138.33%
Number of periportal inflammatory cells
f
e
c
a
d
b
% change
0
23.53%
243.14%
690.20%
78.43%
296.08%
Number of centrilobular inflammatory cells
d
d
c
a
d
b
% change
0
23.53%
200.00%
511.76%
88.24%
320.59%
Number of dilated/congested central veins
c
c
b
a
c
b
% change
0
50.00%
400.00%
1100.00%
150.00%
200.00%
Number of dilated/congested portal veins
c
c
b
a
c
b
% change
0
33.33%
233.33%
666.67%
100.00%
200.00%
Data are presented as and % change ( in each group). Within the same row, values preceded by different superscript letters differ significantly at the 0.05 level (one-way ANOVA and the Tukey test). Eug: eugenol; AgNPs: silver nanoparticles.
