The Ameliorative Role of Eugenol against Silver Nanoparticles-Induced Hepatotoxicity in Male Wistar Rats

Table 3

Immunohistochemical image analysis of the area percentage of Bcl-2, P53, Caspase-3, and TNF-α immunoexpression in hepatic tissues of control and treated animal groups.

Parameters	Animal groups
	Control	Eug	AgNPs-low dose	AgNPs-high dose	Eug + AgNPs-low dose	Eug + AgNPs-high dose
Bcl-2	^a	^a	^bc	^d	^ab	^c
% change	0	-3.98%	-17.99%	-37.91%	-7.96%	-20.94%
P53	^c	^c	^b	^a	^c	^b
% change	0	24.04%	105.77%	202.88%	35.58%	118.75%
Caspase-3	^c	^c	^b	^a	^c	^b
% change	0	25.31%	94.71%	225.64%	39.77%	107.24%
TNF-α	^c	^c	^b	^a	^c	^b
% change	0	20.91%	80.91%	211.82%	30.00%	82.27%

Data are presented as and % change ( in each group). Within the same row, values preceded by different superscript letters differ significantly at the 0.05 level (one-way ANOVA and the Tukey test). Eug: eugenol; AgNPs: silver nanoparticles.