Review Article

[Retracted] Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential

Table 2

Ellagic acid in clinical trials.

Clinical trialsResultsReferences

Exercise performanceImproves strength performance and endurance and accelerates postexercise recovery[278]
Cognitive functionCognitive improvement in overweight men; improves visual learning[279]
Skin conditionsInduce improvement in patients with hyperpigmentation and dark spots[280]
Patients with melasma showed significant improvement after treatment[281, 282]
Lead to increased UV damage protection[283]
Have antiwrinkle activity, increasing the expression of type I collagen mRNA[284]
Insulin resistance and diabetesInduce reduction in blood glucose levels[285, 286]
Weight and body compositionNo significant effect on body weight, body mass index, waist circumference, or body fat percentage[287]
Cardiovascular disease risk factorsDecrease carotid artery intima-media thickness; decrease in mean peak systolic velocity and end-diastolic velocity of carotid arteries[288]
Reduction in stress-induced ischemia[289]
Significant reductions in systolic and diastolic blood pressure[290, 291]
No effect on plasma concentrations of cholesterol, LDL-C, HDL-C, or triglycerides[292, 293]
OsteoarthritisSignificant decrease in WOMAC stiffness and physical function scores[294]
Fatigue, insomniaImprovement in fatigue and insomnia questionnaire scores[295]
Prostate cancerEllagic acid effects as adjuvant therapy for chemotherapeutic treatment: less risk of developing neutropenia than patients receiving chemotherapy alone; PSA reduction; reduction gastrointestinal side effects[296]
Human fertilityIncrease in total number of motile spermatozoa[297]