Molecular Mechanism of Epimedium Extract against Ischemic Stroke Based on Network Pharmacology and Experimental Validation

Table 4

Topological parameters of the hub genes.

Target	Betweenness centrality	Closeness centrality	Clustering coefficient	Degree
TP53	0.11	0.46	0.21	37
JUN	0.12	0.49	0.26	36
AKT1	0.07	0.44	0.19	34
RELA	0.06	0.47	0.28	33
HSP90AA1	0.07	0.46	0.19	32
MAPK1	0.15	0.49	0.23	32
TNF	0.06	0.44	0.30	28
IL6	0.04	0.42	0.34	25
MAPK14	0.02	0.44	0.30	24
ESR1	0.03	0.42	0.32	23
MYC	0.03	0.44	0.42	22
FOS	0.02	0.43	0.32	22
CAV1	0.04	0.43	0.15	19
EGFR	0.03	0.42	0.23	19
RB1	0.02	0.42	0.43	18
CDKN1A	0.01	0.41	0.46	18
MAPK8	0.02	0.41	0.20	18
IL10	0.02	0.36	0.39	18
HIF1A	0.01	0.42	0.50	17
CCND1	0.01	0.39	0.48	17
STAT1	0.02	0.42	0.37	16
CASP3	0.01	0.40	0.36	15
IL4	0.04	0.39	0.54	15
IL1B	0.01	0.39	0.59	15
VEGFA	0.02	0.39	0.30	15
F2	0.15	0.38	0.12	14
IL2	0.01	0.42	0.49	14
MDM2	0.00	0.37	0.42	14
CASP8	0.03	0.40	0.24	14
NFKBIA	0.01	0.42	0.49	14