Research Article
Neurofilament Light Chain (NF-L) Stimulates Lipid Peroxidation to Neuronal Membrane through Microglia-Derived Ferritin Heavy Chain (FTH) Secretion
Figure 2
Effects of FTH-containing exosome on neuronal viability and lipid peroxidation. Cortical neuron was treated with 24 h FTH-containing exosome, after which the cell viability of cortical neurons decreased as measured by CCK8, and the lipid peroxidation levels of neuronal membrane increased as evaluated by C11-Bodipy581/591. Relative quantification of cell viability (a) and area percentage of C11-Bodipy581/591 (b), respectively; the representative images of C11-Bodipy581/591 (c). Values represent (). as compared with control; ## as compared with the 0.5 μg/ml NF-L treatment group; ▲ as compared with the 1 μg/ml NF-L treatment group.
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