Biogenic Selenium Nanoparticles Alleviate Intestinal Epithelial Barrier Damage through Regulating Endoplasmic Reticulum Stress-Mediated Mitophagy

<div>Regulatory effects of SeNPs on PERK and AMPK signaling pathway in IPEC-J2 cells exposed to H<sub>2</sub>O<sub>2</sub>. (a) The expression level of GRP78 was detected by Western blot analysis. (b) The expression levels of PERK, p-PERK, eIF2<i>α</i>, p-eIF2<i>α</i>, ATF4, and CHOP were detected by Western blot analysis. (c) The expression level of p-AMPK/AMPK was detected by Western blot analysis. 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SeNPs: selenium nanoparticles; H<sub>2</sub>O<sub>2</sub>: hydrogen peroxide; XBP1: X-box binding protein 1; GRP78: glucose-regulated protein 78; PERK: protein kinase R-like endoplasmic reticulum kinase; eIF2<i>α</i>: eukaryotic initiation factor 2; ATF4: activating transcription factor 4; AMPK: AMP-activated kinase.</div>

Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Biogenic Selenium Nanoparticles Alleviate Intestinal Epithelial Barrier Damage through Regulating Endoplasmic Reticulum Stress-Mediated Mitophagy 

Figure 2 | Biogenic Selenium Nanoparticles Alleviate Intestinal Epithelial Barrier Damage through Regulating Endoplasmic Reticulum Stress-Mediated Mitophagy 