Biogenic Selenium Nanoparticles Alleviate Intestinal Epithelial Barrier Damage through Regulating Endoplasmic Reticulum Stress-Mediated Mitophagy

<div>Regulatory effects of SeNPs on TM-induced ERS in IPEC-J2 cells. (a) Effect of different concentrations of TM on the viability of IPEC-J2 cells. (b) Effect of SeNPs on the viability of IPEC-J2 cells exposed to TM. (c) Effect of SeNPs the cell morphology of IPEC-J2 cells (scale bar: 50 <i>μ</i>M). (d) Effect of SeNPs on the TEER value of IPEC-J2 cells exposed to TM. (e) Effect of SeNPs on the FITC-Dextran flux cross IPEC-J2 cells exposed to TM. (f) The expression levels of occludin and claudin-1 were detected by Western blot analysis. 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635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,61.846,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>.</span> SeNPs: selenium nanoparticles; TM: tunicamycin; TEER: transepithelial electrical resistance.</div>

Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Biogenic Selenium Nanoparticles Alleviate Intestinal Epithelial Barrier Damage through Regulating Endoplasmic Reticulum Stress-Mediated Mitophagy 

Figure 3 | Biogenic Selenium Nanoparticles Alleviate Intestinal Epithelial Barrier Damage through Regulating Endoplasmic Reticulum Stress-Mediated Mitophagy 