Zingerone Inhibits the Neutrophil Extracellular Trap Formation and Protects against Sepsis via Nrf2-Mediated ROS Inhibition

<div>ZIN inhibited NETs formation and promoted the nuclear translocation of Nrf2 in vivo. (a) The effects of ZIN on NETs production in the lungs of CLP-induced septic mice (histone: green; dsDNA: blue) (fluorescence microscope, magnification ×400). ZIN effects on the levels of MPO-DNA complex in BALF supernatants (b) and cfDNA in plasma (c). 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Zingerone Inhibits the Neutrophil Extracellular Trap Formation and Protects against Sepsis via Nrf2-Mediated ROS Inhibition 