Anticancer Effect of Polyphyllin I in Suppressing Stem Cell-Like Properties of Hepatocellular Carcinoma via the AKT/GSK-3β/β-Catenin Signaling Pathway

Table 1

Binding energies between PPI and β-catenin, p53, PI3K, PPARα, AKT, and GSK-3β based on molecular docking information.

Protein	Gene	UniProt ID	PDB code	Binding energy (kcal/mol)
β-Catenin	CTNNBIP1	Q9NSA3	1JDH	-5.40
p53	TP53	P04637	6GGA	-5.07
PI3K	PIK3R1	P27986	1H9O	-4.66
PPARα	PPARA	Q07869	3SP6	+3.98
AKT	AKT1	P31749	2UVM	-5.51
GSK-3β	GSK3B	P49841	1GNG	-5.32